Leicester and Northampton both won to book LV= Cup semi-final spots, while Scarlets also managed a last-four spot despite losing at Sale.
Leicester saw off Newcastle 24-13 at Welford Road.
Toby Flood came through half an hour of action from the bench in a boost to the England management, as the home fly-half returned from a knee injury with no ill-effects.
George Skivington and Thomas Waldrom scored Leicester's two tries with their other points coming from the boot of Jeremy Staunton while Jamie Helleur crossed for the visitors.
England flanker Hendre Fourie scored a try on his home debut to give Sale a 19-14 victory but Scarlets were still able to progress.
Scarlets' bonus point, coupled with defeats for their pool rivals Gloucester and Newcastle, guaranteed their passage into the last four.
Welsh fly-half Nick Macleod kicked 14 points against his compatriots while Fourie had an outstanding game on his first match at Edgeley Park since his move from Leeds in the summer.
Northampton also booked a place in the semi-finals with England Under-20 winger Jamie Elliott scoring twice in their eight-try 57-10 romp against Wasps.
The Saints dominated throughout against a hopelessly out-of-form Wasps side to ensure that Exeter cannot catch them in Pool Four, regardless of their result against Bath on Sunday.
As well as a penalty try, Noah Cato and Jamie Elliot both scored two each while James Craig, Andy Long and Alex Waller also crossed.
Joe Simpson scored Wasps' only try of the match with their other points coming from Nicky Robinson and William Robinson.
A masterly kicking display from London Irish full-back Tom Homer condemned defending champions Gloucester to a 23-15 defeat.
But it was young Gloucester winger Ian Clark who stole the show with two tries, one of them an outstanding solo effort, on his starting debut for the Cherry and Whites.
Homer kicked six out of six penalties, with hooker Brian Blaney grabbing an early try for the Exiles.
Worcester completed their campaign with a hard-fought but deserved 24-14 win over a competitive Ospreys at a freezing Sixways.
Whatever the result of the game, both sides knew at the outset that they were unable to progress to the semi-finals of the competition but still produced a very spirited contest in most difficult conditions.
Two tries from Josh Drauniniu and one from Jake Abbott - as well as nine points from the boot of Andy Goode - contributed to the Warriors' win while Matthew Morgan and Hanno Dirksonall both crossed for Ospreys.
Show your love for the New Zealand All Blacks with the official t-shirt.
Price: $17.99 Buy at World Rugby ShopSupport the U.S.A. Eagles as they represent the country in international test matches.
Price: $89.99 Buy at World Rugby ShopSupport your favorite rugby team with an official rugby training ball. Check out what is available.
Price: $19.99 Buy at World Rugby ShopWorld Rugby Shop has the best selection of rugby shorts.
Price: $19.99 Buy at World Rugby ShopCanterbury of New Zealand makes some of the best rugby specific rugby boots.
Price: $79.99 Buy at World Rugby ShopSuper Rugby has some of the coolest rugby jerseys. Check out the Chiefs jersey.
Price: $79.99 Buy at World Rugby ShopGet a new rugby team jersey for your 7's team this summer. Great prices, great styles.
Price: $49.99 Buy at World Rugby ShopThe Australia Wallabies are one of the top southern hemisphere teams. Get in the Gear.
Price: $104.99 Buy at World Rugby ShopA cool cap from a great rugby playing country, Tonga. Show your love for the global game.
Price: $19.99 Buy at World Rugby Shop
Rugby Match Ticker
Follow LIVE rugby action from around the globe with Rugby Rugby!
The World Rugby Shop has the best selection of official and team rugby gear from around the globe. Shop for your rugby gear today!